Transhumanism is the concept of overcoming the limits of human biology with science and technology. Today, changes brought by transhumanist technologies—such as AI, blockchain, and brain-computer interfaces—are creating an uncertain future for companies and our careers. The average life span of companies today has dropped significantly since decades ago, and the life span of our careers is also expected to exponentially decrease. Will there be enough jobs for us all? If so, what skills are needed? And how do we start obtaining these skills?